Douro Valley is located north/interior of Portugal, considered one of the most beautiful wine regions in the world (and the oldest!).
The easiest way to reach Douro Valley from Lisbon, is by car.
Please see my article here: https://lisbonguide.org/car-transfer-from-lisbon-to-douro-valley/
But, some guests might prefer to check alternative options for transportation by public train.
There are several trains departing from Lisbon to Douro Valley. Most of the trains will have 7-10 stops, and you will need to change trains in Coimbra and/or Porto.
It takes around 5h30 to 6h, including stops on each station. There are no direct, nonstop trains to Douro, will be required to change trains.
All trains are operated by CP.
You can find more information on their website: https://www.cp.pt/
For example, searching for next month, I see 11 trains leaving to Douro (Regua). The first one departs 7h30AM from Lisbon Oriente, towards Coimbra, , stopping 7 times. Then, change train in Coimbra, heading to Porto (wiuth 4 stops). Finally in Porto, change trains again, and head to Peso da Regua, stopping 11 times.
Once arrived at Peso da Regua, you will need to find alternative transportation to reach your final destination, since most hotels/accommodations are not walking distance.
Regarding Pinhão, there are less options, and longer (6h to 7h), but yopu might arrive to Regua and then take a taxi to Pinhao, for example (30min).
To Lamego, there are no options.
For other areas of Douro, you would have to check one by one, if they have a train passing by.
Hope this information can help, any questions just ask.
For car transfer service from Lisbon to Douro Valley, starting at 395EUR, please check below:Link: https://lisbonguide.org/car-transfer-from-lisbon-to-douro-valley/
Questions? Drop-me a message below or text me on WhatsApp here: http://whatsapp.lisbonguide.org/